Vasculitis refers to a group of rare disorders caused due to inflammatory changes in blood vessels, which are often triggered due to immunological dysfunctions. Large blood vessels together with small capillaries, that help in the circulation of the blood all over the body, form the vascular system. Vasculitis, or inflammatory changes in these blood vessels, can affect the blood supply to the vital organs thereby increasing the risk of several disorders. Hence, it is important to assess the role of the immune system in triggering the development and causes of vasculitis so that appropriate steps can be taken to control this condition. The symptoms of vasculitis can be generalized or related to a particular organ or part of the body. The generalized symptoms of this disease include fever, weight loss, fatigue, and muscle or joint pain. Patients may also experience pain in the abdomen, skin rashes, ulcers, abnormal sensations of pins and needles, and shortness of breath. This article is focused on assessing the role of immune system dysfunction that contributes to the causes of Vasculitis. We will also discuss the importance of correcting immunological abnormalities to control this illness.

How do immune system dysfunctions contribute to the causes of Vasculitis?

Abnormal innate and adaptive immune responses

It is known that just like the immune system, blood vessels are also distributed widely across the body to reach all the organs and tissues. Blood vessels offer the mode of transport for immune cells to reach the target tissues where they can act to destroy pathogens, heal the injured tissues and perform various functions. However, this widespread flow of immune cells through the blood vessels makes the arteries and veins prone to Vasculitis. Abnormally functioning adaptive and innate immune cells can cause damage to the blood vessels resulting in inflammatory changes as these cells flow through them. This form of inflammation initiated due to faulty immune cells can affect large blood vessels like the aorta resulting in large vessel vasculitides. Inflammation infiltrates the walls of the aorta and the major branches and usually displays a unique microarchitecture in the forms of granulomatous lesions. These blood vessels supply blood to the heart and other vital organs. A compromised blood flow due to Vasculitis can increase the risk of myocardial infarction, cerebrovascular stroke, and several life-threatening disorders. Hence it is important to identify the immunological causes of Vasculitis and correct the abnormality to prevent the development of these consequences.

A weak immune system

A weak immune system has been found to be one of the common causes of Vasculitis linked to infective damage to the blood vessels. Research studies have also shown that viral infections can trigger the development of Vasculitis. An infection with the Hepatitis C virus is more common in patients with mixed cryoglobulinemia, which is an immune complex-mediated form of Vasculitis. The Hepatitis C virus participates in the formation of immune complexes that contribute to the causes of Vasculitis. The risk of Vasculitis can be lowered significantly by using immunity-boosting supplements that strengthen the response of the immune system to Hepatitis C and other viruses. This is believed to be an effective preventive approach for reducing the risk of infection-linked development of Vasculitis.

Abnormal activation of the innate immune

It has been found that the polymorphisms that influence the activation of innate immune cells can predispose a person to the development of Vasculitis. It can also influence the severity of this illness. Abnormally activated immune cells tend to interact with other cells of the immune system and activate the B and T lymphocytes thereby triggering the causes of Vasculitis. These factors result in the widespread destruction of blood vessels via cell-mediated cytotoxicity and the release of pro-inflammatory cytokines. Hence, adopting measures to regulate immune system functions is recommended to control the immunological causes of Vasculitis. Patients diagnosed with Vasculitis are advised to use BioPro-Plus to improve their immunity. BioPro-Plus is an immunity-boosting supplement, which can regulate the response of immune cells and prevent inflammatory damage to the blood vessels. Regular use of this supplement can ensure a smooth blood flow to all organs and tissues and prevent the risk of serious complications by controlling the immunological causes of Vasculitis.

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