What are the immunological causes of Rheumatoid arthritis?
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Rheumatoid arthritis is a chronic condition affecting the joints and is marked by symptoms caused due to damage and inflammation. This disease occurs due to abnormalities related to the immune system the immunological causes of Rheumatoid arthritis are responsible for the chronic nature of this disorder.
Rheumatoid arthritis is characterized by periods of remissions and exacerbations. Patients do not experience much discomfort during the period of remissions. However, the periods of exacerbations are characterized by severe joint pains, swelling, stiffness, and the loss of joint function.
Here is a brief discussion about the immunological causes of rheumatoid arthritis responsible for the development and exacerbation of this disorder. We will also have a look at why it is important to control and regulate immune system functions to derive relief from the symptoms of rheumatoid arthritis.
How does an abnormal immune response trigger the causes of rheumatoid arthritis?
Triggers inflammation
The primary causes of rheumatoid arthritis are linked to chronic inflammation occurring in the joints. Research studies have shown that rheumatoid arthritis is a form of inflammatory arthropathy having an immune-mediated pathogenesis.
Abnormalities of the immune system can cause stromal tissue dysregulation, which can further worsen the inflammatory changes in the joints and articular destruction thereby causing exacerbations of rheumatoid arthritis.
The higher concentration of inflammatory chemokines and cytokines in patients diagnosed with this condition have confirmed this theory. This is why patients are advised to adopt strategies to regulate the immune system response to control the symptoms and immunological causes of rheumatoid arthritis.
Production of antibodies
Rheumatoid arthritis is considered an autoimmune disorder as it occurs due to an abnormal response of the immune cells to the body’s own healthy tissues of the joints. It has been found that the clinical manifestations of this condition become worse due to an excessive production of anticitrullinated protein antibodies by immune cells.
The immune cells fail to recognize the tissues of the bones and joints as the body’s own, and thus, triggers a reaction that results in the production of these antibodies aimed at causing the destruction of cells.
This triggers the development and causes of rheumatoid arthritis resulting in damage and inflammation of the affected joints. The result of this study suggests that taking steps to correct the abnormal response of the immune system could control the damage to the joints thereby preventing the development of rheumatoid arthritis.
The role of innate immunity
Research studies have proven the role of innate immunity in contributing to the pathogenesis of rheumatoid arthritis. The clinical symptoms of this disease such as pain, swelling, stiffness, and joint destruction are linked to the chronic inflammatory changes occurring in the synovium of the joints.
These changes are characterized by the interactions of the fibroblast-like synoviocytes with the cells produced by the innate immune system such as macrophages, mast cells, dendritic cells, and NK cells.
Also, the presence of immune complexes, cytokines, and chemokines that possess inflammatory properties also indicate the possible role played by the immune system in triggering the development and causes of rheumatoid arthritis.
Hence, controlling immune system function is recommended to prevent the flaring up of rheumatoid arthritis.
The results of these scientific studies have proven the role of the immune system in the pathogenesis of rheumatoid arthritis. It is suggested that regulating the response of the immune system can help control the production of autoantibodies as well as pro-inflammatory substances such as cytokines thus relieving the symptoms of rheumatoid arthritis.
The use of immunity-balancing supplements like BioPro-Plus is advisable for patients diagnosed with rheumatoid arthritis, considering the role of the immune system in the development of this disease. BioPro-Plus is formulated to help improve the symptoms of disorders linked to a faulty immune system by regulating immune functions and inhibiting the abnormal autoimmune response.
Regular use of BioPro-Plus would help to prevent inflammatory changes in the joints and bones through its regulatory effect on the immune system thereby assisting in preventing joint pain and other symptoms of this disease. Use of BioPro-Plus is also recommended to help protect joint tissues against the damage caused by autoantibodies through its ability to help control the autoimmune causes of rheumatoid arthritis.
