Back pain is a common symptom affecting men and women of all ages. Lumbar spondylosis is a common cause of back pain, especially in the elderly population. Research studies have revealed that aging and immunological dysfunctions are the common causes of lumbar spondylosis. Lumbar spondylosis is a common disorder known to progress gradually and cause considerable restriction of movement. Age-related degeneration in the vertebrae of the lumbar region can become worse due to inflammatory damage and immunological abnormalities. As a result, patients may develop severe pain in the lower back that is usually worse after strenuous physical activities. Hence, patients should be aware of the immunological causes of lumbar spondylosis and seek appropriate treatment to prevent the worsening of the condition.

What are the immunological causes of lumbar spondylosis?

Promotes degeneration

Lumbar spondylosis is a chronic degenerative condition affecting the vertebral column. It can affect also the intervertebral discs between 2 adjacent vertebrae and the vertebral bodies in the lumbar region of the backbone. Lumbar spondylosis is often ignored by patients believing it to be a part of aging. However, if not managed properly, the degenerative damage in the lumbar vertebrae can progress further resulting in severe symptoms like pain and restriction of movements that can limit the patient's routine activities considerably. Research studies have shown that ignoring the early degenerative changes in the lumbar region or the precursor of this condition like ankylosing spondylosis could accelerate the damage to these joints. It has also been revealed that innate cytokine and immune cells play a crucial role in the pathogenesis and causes of lumbar spondylosis and ankylosing spondylosis. Untreated ankylosing spondylosis could cause spinal deformity that can worsen the symptoms of lumbar spondylosis. Hence, it is advisable to identify the immunological causes of lumbar spondylosis to relieve the symptoms and slow down the progress of this disease.

Inflammatory back pain

Inflammatory back pain caused due to lumbar spondylosis could be relieved to some extent by using medications that regulate immune system functions. Research studies have suggested that in severe cases of lumbar spondylosis the use of pain killers like NSAIDs may not help to provide much relief. In such cases, the use of medications that affect the patients’ immune response such as TNF-inhibitors are often recommended. These drugs work by controlling the response of the immune cells thereby lowering the release of the pro-inflammatory substances. However, there are serious risks associated with these medications, as other essential immune activities are also suppressed. Read more about those risks here: Risks of TNF-Inhibitors that You Must be Aware of.

Proinflammatory cytokines

Research studies that have assessed the role of proinflammatory cytokines such as IL-19 and IL-20 in the pathogenesis of lumbar spondylolysis have revealed interesting results. Research studies have suggested that the degenerative changes occurring due to lumbar spondylolisthesis could lead to serious complications such as spinal canal stenosis. These degenerative changes can also contribute to a reduction in the space between the two lumbar vertebrae. This can lead to the compression of the intervertebral discs due to which the nerve passing through this space can be damaged. Research studies have shown that these abnormal changes in the lumbar region can become worse due to the chemotactic, angiogenic, and proinflammatory cytokines like IL-19 and IL-20 released by the immune cells. The increased secretion of these cytokines is linked to the higher risk of several chronic inflammatory disorders affecting the bones and joints like rheumatoid arthritis, intervertebral disc herniation, osteoporosis, and fractures. These studies indicate the need to correct the immunological abnormalities that can trigger the causes of lumbar spondylosis in order to inhibit degeneration and inflammation. Identifying the immunological causes of lumbar spondylosis could help to slow down the degenerative changes and inflammation in the lumbar region. Patients can use immune-modulating supplements like BioPro-Plus to help correct the immunological dysfunctions. BioPro-Plus could help to regulate the functions of the immune cells and inhibit inflammation in the lumbar vertebrae and intervertebral discuss. This could help to slow down the progression of lumbar spondylosis and help patients remain active in their senior years.

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