Sjögren’s Syndrome is a condition caused due to abnormalities linked to the immune system. The common symptoms of this disorder include dryness of eyes and mouth. The immunological causes of Sjögren’s Syndrome result in damage to the moisture-secreting glands and mucous membranes in the eyes and mouth resulting in dryness.

Sjögren’s Syndrome is usually accompanied by other immune system disorders like rheumatoid arthritis or lupus. Although Sjögren’s syndrome can occur at any age, it is more common in people older than 40 years. This condition is more common in women.

The other symptoms of Sjögren’s syndrome include burning, itching of the eyes and a sensation as if the mouth is full of cotton, resulting in difficulty swallowing and speaking. This condition can also cause serious health complications, so this article is focused on assessing the need to control the immunological causes of Sjögren’s Syndrome to prevent these issues.

How does an abnormal immune system trigger the causes of Sjögren’s Syndrome?

Autoimmune response

Research studies have indicated that Sjögren’s Syndrome is an autoimmune disorder. An abnormal response of the immune system causes the immune cells to attacks healthy cells in the lachrymal glands and the salivary glands resulting in dry eyes and dry mouth.

These changes usually occur due to the involvement of the adaptive immune system. The presence of auto-antibodies and lymphocytic infiltrates in these glands have provided evidence to support this theory.

It was also observed that damage to the glands also occurs when the immune system stimulates the release of Interferon regulatory factor-5, which is a transcription factor that mediates IFN- and virus-induced signaling pathways. This can trigger infections of the cells that may result in the worsening of the symptoms of Sjögren’s Syndrome. Hence, correcting immune function is advisable to control the cause of Sjögren’s Syndrome.

causes of Sjögren's syndrome

Innate immunity

Research studies have suggested that immune system dysfunctions can result in an exaggerated response of the cells linked to innate immunity resulting in the development of Sjögren’s Syndrome.

The innate immune system can trigger the causes of Sjögren’s Syndrome and play a role in the pathogenesis of the condition. It has been proven that the functions of the innate immune cells and their pathways are dysregulated in the exocrine tissues and peripheral blood in patients diagnosed with Sjögren’s Syndrome. The results of this study have indicated the need for regulating immune system functions to avoid triggering the causes of Sjögren’s Syndrome.

Inflammatory changes

Scientific research has shown that the immune system may contribute to the development and causes of Sjögren’s Syndrome by initiating inflammatory changes in the salivary and lachrymal glands. Dysfunctions of the immune system can result in the release of natural killer cells, natural killer T cells, and interleukin, which worsen the damage to these glands thus triggering the development of Sjögren’s Syndrome.

Also, the serum cytokine levels of interleukin-4, interleukin-6, interleukin -10, as well as tumor necrosis factor-alpha have been found to be higher in the patients diagnosed with this syndrome. These findings provide evidence to confirm the role of immune system dysregulation in triggering Sjögren’s Syndrome.

Patients diagnosed with Sjögren’s Syndrome are advised to use immune system support supplements such as BioPro-Plus to help control the symptoms in a safe and effective manner. This supplement is formulated to help balance immune system functions to avoid inflammatory changes and an autoimmune response.

This can help to protect the salivary and lachrymal glands against damage caused by the faulty response of the immune system and relieve the symptoms of Sjögren’s Syndrome. Regular use of BioPro-Plus could restore the natural health of these glands by controlling the causes of Sjögren’s Syndrome.

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