Graves’ disease is a form of autoimmune disorders that occur due to the higher production of thyroid hormones by the thyroid gland. Graves’ disease is usually the underlying cause or the precursor for hyperthyroidism. The immunological causes of Graves’ Disease such as the abnormal response of the immune system to healthy thyroid cells can worsen the symptoms of this disease.
The common symptoms of Graves’ disease include unexplained weight loss, anxiety, tremors, restlessness, palpitations, irritability, insomnia, and excessive sweating. The immunological abnormalities that trigger the development of this condition are often genetic in origin. Hence, this disease is known to run in families.
This article is focused on providing information about the role of the immune system in triggering the causes of Graves’ disease. We will also discuss the importance of correcting immunological abnormalities for relieving the symptoms of this condition.
The role of the immune system in triggering the causes of Graves’ Disease
Release of cytokines
Research studies have revealed that the excessive production and release of cytokines by the immune can be responsible for triggering the pathogenesis of Graves’ Disease.
Studies have shown that the causes of Graves’ disease are linked to the loss of immune tolerance and a higher reactivity of the thyroid gland to thyroid autoantigens including thyroid peroxidase, thyroid stimulating hormone receptor, and thyroglobulin.
This results in the infiltration of the thyroid gland by the T and B cells, which produce antibodies that cause significant damage to the gland resulting in the clinical manifestations of Graves’ disease.
The results of this study indicate the possibility of controlling the causes of Graves’ disease by correcting the underlying abnormal reaction of the immune system.
Recent scientific investigations have proven that immunodeficiency can play a role in supporting the pathophysiology and the causes of Graves’ Disease.
It was revealed that the symptoms of Graves’ Disease may worsen due to immunodeficiency and an abnormal response of T cells when the T cell receptors that recognize the autoantigens are destroyed due to apoptosis through the process of negative selection.
Also, it was found that the risk of familial autoimmune thyroiditis or Graves’ Disease was higher in patients who suffered from the deficiencies in CD3γ. The findings of this study indicate the Posse mechanism by which immunodeficiency can trigger the causes of Graves’ disease.
Releases antigen-reactive T and B cells
An abnormal response of the immune system may be responsible for stimulating the causes of Graves’ disease by causing a release of antigen-reactive T and B cells. The presence of lymphocytic infiltrate in the thyroid gland, and the higher levels of antigen-reactive T and B cells in patients diagnosed with Graves’ disease have indicated this hypothesis.
Research studies have also shown that the pathogenesis of Graves’ disease can also occur due to the breakdown in the tolerance mechanisms at the central and peripheral levels, which is linked to abnormal immune system functioning.
Hence, taking steps to correct underlying immune system abnormalities is highly recommended to control the symptoms of Graves’ disease.
The findings of these research studies reveal the role of the immune system in contributing to the development of Graves’ disease. Patients diagnosed with this condition are advised to seek immunological intervention to help correct the functions of the immune system using BioPro-Plus.
BioPro-Plus is an immunity-modulating supplement that has been formulated to improve the normal functions of the immune system. It can also be beneficial for patients who suffer from Graves’ disease due to immunodeficiency or an autoimmune response to the healthy tissues of the thyroid gland. It can help to inhibit the development and progress of this condition by controlling the immunological causes of Graves’ disease.